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A similar metabolic mode of negative regulation of NLRP3 inflammasomes occurs via nitric oxide [118,119,120] generated downstream of pro-inflammatory stimulus-mediated transcription of the nitric oxide synthase 2 gene or inducible nitric oxide synthase (iNOS)

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However, blocking fatty acid oxidation (FAO) in renal tubular epithelial cells can promote intracellular lipid deposition during the fibrotic process

Every 8 to 12 weeks during treatment: Repeat the panels above